CCB) is one of the research departments of VIB (Vlaams Instituut Biotechnologie) located in KU Leuven Campus Gasthuisberg.
CCB hosts 12 research groups with an employment of about 250 researchers, administrative and technical collaborators.
is especially focusing on the development of blood vessels (Angiogenesis) and vascular metabolism, and consists of 60 driven researchers and lab technicians.
The Lab is looking for a dynamic and highly motivated PhD student to join the team.
The focus of the lab is to characterize the regulation of cell metabolism and to determine the role of metabolism during the process of angiogenesis.
Angiogenesis, the growth of new blood vessels, plays a crucial role in numerous diseases, including cancer. Inhibiting the formation of vessels within the tumor (anti-
angiogenic therapy) has emerged as a promising anti-cancer strategy. Clinically approved anti-angiogenic drugs offered prolonged survival to numerous cancer patients.
Unfortunately, monotherapy with the current available anti-angiogenic agents often results in the development of treatment resistance.
Thus, novel strategies are needed to block tumor angiogenesis via alternative mechanisms. The tight interaction between blood vessels that provide metabolic substrates, and the tumor cells that utilize them, leads to the obvious link between metabolism and angiogenesis, surprisingly this has not been studied so far.
Recent studies from the lab revealed that targeting endothelial metabolism could be a possible alternative therapeutic strategy for anti-
angiogenic therapy. In this perspective, we are aiming to investigate several metabolic pathways in different models of angiogenesis.
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