Senior/Principal Scientist Oligonucleotide Analytical Chemistry
Johnson & Johnson
Beerse, Belgium
4 dagen geleden

Within Janssen R&D, a member of Johnson & Johnson's Family of Companies, we are recruiting a Principal or Senior Scientist in Oligonucleotide Analytical Chemistry based in Beerse, Belgium to support the analytical development of our growing Oligonucleotide portfolio.

Janssen Research & Development area develops treatments that improve the health and lifestyles of people worldwide. R&D development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, pulmonary hypertension and reproductive medicine.

The Principal or Senior Scientist in Oligonucleotide Analytical Chemistry will be employed in the Analytical Development (AD) organization, responsible for all analytical activities in CMC (Chemistry Manufacturing & Controls) development.

The Principal or Senior Scientist in Oligonucleotide Analytical Chemistry will join the Advanced Material Characterization and Investigations (AMCI) group within Analytical Development.

AMCI is an international and diverse team of scientists leading global analytical investigations for the Small Molecule R&D and Commercial product portfolio, of which part will be conducted in the Advanced Molecular Analysis (AMA) team.

Situated within the AMA group are Analytical centers of excellence in structure elucidation (by High-resolution Mass Spectrometry and NMR), excipient & polymer characterization and Oligonucleotide &Peptide Analytics.

The AMA group is currently looking for a highly motivated Principal or Senior Scientist in Oligonucleotide Analytical Chemistry to join their team.

For this laboratory-based position, the successful candidate will work together with internal oligonucleotide process chemistry, drug product development and analytical development teams to find innovative solutions for in-depth characterization of therapeutic oligonucleotides.

Key Responsibilities :

  • Develop analytical strategies for the advanced and in-depth characterization of oligonucleotide therapeutics (ASO, siRNA, etc.
  • in development, including their starting materials and intermediates.

  • Contribute to defining scientific strategies and goals for oligonucleotide development within a multidisciplinary project team setting.
  • Collaboratively support the advancement of oligonucleotide compounds through the different stages of development.
  • Work independently with a high level of productivity to solve challenging analytical problems.
  • Present data and reports on project status at individual, group, and departmental meetings.
  • Provide scientific direction and serve as a scientific expert for oligonucleotide-related analytical chemistry activities, keeping abreast of novel analytical technology.
  • Qualifications

  • A PhD in (Analytical) chemistry, biochemistry or related field with relevant experience.
  • A master’s degree in chemistry, biochemistry, or related field with 5 to 10 years of relevant experience is required.
  • Practical experience in analysis of oligonucleotide-related compounds is required, additional experience with peptides is considered an advantage.
  • Preferably hands-on experience with LC and mass spectrometry in the area of nucleoside / nucleotide or oligonucleotides.
  • Knowledge of other analytical techniques like circular dichroism spectroscopy, UV, NMR, or other spectroscopic techniques, as well as DSC is an advantage.
  • Experience with characterization of the higher-order structure of oligonucleotides is an advantage.
  • Strong track record of scientific contributions including peer reviewed publications, or patents, or presentations at major national meetings is considered a plus.
  • What is in it for you?

  • Contributing to our mission to continue to bring transformational new medicines to patients for a world without disease.
  • Being part of a motivated and experienced research team in an innovative working environment
  • Through mentoring programs, e-university and on the job training, we ensure your personal development in a global company
  • A competitive salary, 39 holidays, on-site sport accommodations, health / energy programs and other benefits for you and your family
  • Johnson & Johnson Family of Companies are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law.

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