Scientific collaborator – Stimulating regulatory uptake of an innovative platform for cardiotoxicity evaluation
Sciensano
Brussels, BE
3 dagen geleden

Functiebeschrijving

You will be responsible for the work package Regulatory uptake’ within the European research project environmentAL Toxicology of chEmical mixtuRes through aN innovATIVE platform based on aged cardiac tissue model (ALTERNATIVE).

You will join the service Risk and Health Impact Assessment. You will collaborate with different international partners of the ALTERNATIVE project and in particular with the Medical University of Innsbruck.

ALTERNATIVE will develop an innovative platform able to detect the cardiotoxicity of chemicals and their biotransformation products.

The novel platform will enable regulators and industry to identify, quantify and prevent cardiotoxic co-exposures to industrial chemicals and pharmaceuticals in a cost-effective way.

The platform will consist of a three-dimensional tissue engineering in-vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses, and integrated into a Machine Learning (ML) risk assessment tool.

Within the project, Sciensano is responsible for ensuring that the developed platform meets the regulatory needs and to stimulate its regulatory uptake.

To this extent, the platform will be developed within the adverse outcome pathway framework and its place within an integrated approach for testing an assessment will be defined.

Your tasks will include

  • Collection of information on chemicals inducing cardiotoxicity;
  • Documentation of regulatory needs for cardiotoxicity methods and data;
  • Design of novel and / or extension of existing AOPs for cardiotoxicity;
  • Linking of information collected with the ALTERNATIVE platform to the AOPs;
  • Designing the outline of an IATA for cardiotoxicity;
  • Drafting of guidance for regulatory use of cardiotoxicity data collected with the ALTERNATIVE platform;
  • Participating in project meetings;
  • Presentation of research results at congresses and valorisation in peer reviewed publications.
  • PhD in Toxicology.

    Experience with the AOP concept and / or IATA development is an asset.

    Willing to work independently in the context of the research project and to collaborate with different European partners.

    Interest in new approach methodologies.

    Excellent knowledge of English

    Behavioral competencies :

  • Result and solution-oriented working
  • Precise, enterprising and stress resistant
  • Good communication skills (incl. written reporting, scientific presentation)
  • Able to work independently
  • Wij bieden

    Een uitdagende functie in een bekend wetenschappelijk instituut

    Arbeidsovereenkomst van bepaalde duur (3 jaar)

    Weddeschaal : SW21

  • Voordelen : gratis abonnement of 100% terugbetaling woon-werkverkeer met het openbaar vervoer; hospitalisatie- en groepsverzekering;
  • maaltijdcheques; voordelen via FED+ (www.fedplus.be); andere sociale voordelen

    Andere : glijdende werkuren in een 38-uren week; mogelijkheid tot telewerk en opleidingen

    deze vacature melden
    checkmark

    Thank you for reporting this job!

    Your feedback will help us improve the quality of our services.

    Solliciteren
    Mijn E-mail
    Door op "Doorgaan" te klikken, betekent dit dat je neuvoo toestemming geeft om je gegevens te verwerken en je e-mails met vacatures te sturen, zoals beschreven in neuvoo's -Privacybeleid . Je kunt je toestemming altijd intrekken
    Doorgaan
    Aanvraagformulier