About the lab
headed by Thomas Voets, is a vibrant and international research team, embedded in the VIB-KU Leuven Center for Brain and Disease Research (VIB-CBD) and the KU Leuven Department of Cellular and Molecular Medicine.
Research within LICR is focused on transient receptor potential (TRP) ion channels, and we use a large variety of molecular, cellular, and in vivo approaches to study their functional properties, cellular regulation and (patho)physiological roles.
Moreover, through intense collaborations with clinical and industrial partners, we aim at translating this knowledge into new TRP channel-based therapies for important medical conditions including chronic pain, diabetes, cardiac disease, and bladder dysfunction.
The lab is engaged in the BioInspireSensing project. This project is a trans-national training network inaugurated to train Ph.
D. students in investigating, building, and producing a new generation of bioinspired implantable sensors of pressure, temperature and acidity.
anticipating thus, a new generation of sensors that would not require posterior surgical extraction. BioInspireSensing will take advantage of a unique multi-sectoral and multi-field environment to further teach early-stage researchers (ESR) to apply the gained knowledge in analyzing and designing / engineering complex biological nanosensors of medical importance.
BioInspireSensing includes a unique combination of research training, industry placements, as well as courses and workshops on scientific and complementary soft skills.
In the framework of the BioInspireSensing project we are currently looking for a talented and motivated Ph.D. student to join the team and work on the development of TRP channel-based sensors for temperature with optimization of their properties, such as sensitivity, sustained response, selectivity and stability.
This will be achieved by site-directed mutagenesis of naturally occurring temperature-sensitive TRP ion channel proteins (e.
g. TRPM8, TRPV1), recombinant expression of mutants, and characterization of their properties using electrophysiological and imaging techniques.
The aim is to develop channels that are selectively tailored to sense different ranges of temperature in a stable and environment-independent manner.
The best channel constructs will be expressed in cells for purification and insertion in lipid bilayers.
in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date.
Short stays, such as holidays, are not considered.
This is measured from the date when they obtained the master’s degree or an equivalent degree.
Start date of the position : 1st October 2021
How to apply?
Please apply through the for one to a maximum of three positions, and provide the required information (in English) in one PDF file alone with the following order :
All required information has to be packed in one PDF file alone in the order shown above and using a file name with the following format : surname name ESRXX.
pdf where XX is the ESR position number to which are applying, i.g., 01, 02, etc.
For more information :