In vivo Technician
Charles River Laboratories, Inc.
Beerse, BE
4 dagen geleden

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies.

When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform.

In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are seeking an experienced in vivo Technician to join our Discovery site located in Beerse. The Technician will mainly help to develop and conduct in vivo assays / models with Mycobacterium tuberculosis to evaluate the efficacy of new anti-tuberculosis compounds, alone and in combination.

He or she will also assist with the various in vitro M. tuberculosis assay currently in place at the Biosafety Level 3 laboratory.

All this is done in a team-oriented, result-driven, international research environment.

Job Responsibilities

  • Plan and conduct in vivo infection studies in mice :
  • o Prepare and schedule experiment

    o Be the point of contact for animal caretakers / weekend support

    o Ordering of mice and compounds

    o Intranasal infection of mice by using anaesthesia

    o Weighing, blood sampling and euthanasia of mice

    o Collection and processing of organs / blood samples

    o Animal and sample administration

  • Provide ad hoc support for in vitro microbiological analyses (e.g. time kill kinetics, compound profiling).
  • Analyse and interpret obtained data and prepare detailed lab reports in an ELN system according to departmental standards.
  • Establish an understanding of the relevance of the data being generated on the project.
  • Present own work confidently, internally, with clear rationale and produce slides on own work.
  • The following are minimum requirements related to the Technician position :

  • B. Sc. or M.Sc. with minimum 2 years of working experience in a relevant environment.
  • Experienced in all requested aspects of in vivo mouse work.
  • Experience in working with infectious agents in a Biosafety Level 3 laboratory is preferred.
  • Experience in microbiological techniques (working in sterile environment, handling bacterial cutures etc) is a plus.
  • Good planning and organizational skills.
  • Excellent communication skills in English.
  • Flexible mindset, good record keeping skills and attention to detail are essential.
  • About Discovery

    Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years.

    Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND.

    Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

    About Charles River

    Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development.

    Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities.

    Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

    With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges.

    Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

    And in 2019, revenue increased to $2.62 billion.

    At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe.

    We have proudly supported the development of 85% of the drugs approved by the FDA in 2019.

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