Senior Specialist - Downstream Process Development Microfluidics & Small-Scale
Rixensart, Brabant wallonBelgique
2 dagen geleden

Oct 13 2020

Your Responsibilities :

  • You will be responsible for the design and execution of purification experiments in a large variety of R&D projects (DNA, proteins, polysaccharides, viral vector).
  • You will implement high-throughput and robotic technologies towards automation of purification experiments (liquid handlers, TECAN & Hamilton systems).
  • You will develop modelling capability and Process Analytical Technologies (PAT) for accelerating purification towards online analytics and in-silico process development.
  • You will investigate microfluidics and continuous alternatives for purification process steps, targeting low footprint, continuous and modular process development.
  • You will report the results in a comprehensive form after statistical interpretation and extensive quality check of the raw data.
  • You will also suggest improvements and offer perspective for further developments.

  • Your responsibility will also include writing experimental procedures and scientific reports, prepares and presents scientific data, defend scientific and technical decisions at the appropriate technical board, etc.
  • You will make sound scientific and technical decisions based on a balance of data, analysis and experience.
  • You will ensure proper transfer of purification processes and in-process assays to internal or external partners such as Scale-up, Clinical Manufacturing, etc.
  • You will ensure proactive scientific / technology watch within your own competency domain.
  • You will provide scientific and technical leadership in your own area of expertise and spread knowledge across the whole organization, also supporting other vaccine projects upon needs.
  • You will improve the process of understanding and control to meet the growing requirement by Regulatory Authorities through capability building.
  • You might also be responsible for the technical follow-up of external collaborations.
  • Why you?

    Basic Qualifications :

    We are looking for professionals with these required skills to achieve our goals :

  • Ph.D. in sciences or equivalent acquired through professional experience (Chemistry, Biochemistry or Biotechnology orientation), Bio-Engineering degree, Master’s Degree in (Bio)-Chemistry or Biology.
  • Solid experience in purification process development (at least 4 to years in Biopharma related domain).
  • Demonstrated knowledge and competency in the specific area of the purification and analysis of biologic material such as DNA, proteins, polysaccharides, viral vectors.
  • Experience in PAT and high-throughput technologies & automated equipment (recipe setup and execution) for the purification process.
  • Experience with liquid handler robots (TECAN, Hamilton).
  • Experience in Project Management.
  • Good understanding of Biopharma / Vaccine development processes as well as knowledge of analytical techniques for biological material.
  • Good stakeholder management and excellent communication skills are necessary to meet needed mindset and behavioral changes that will be required by the business.
  • Fluent in spoken and written English a must. French and / or Italian a plus.
  • Preferred Qualifications :

    If you have the following characteristics it would be a plus :

  • Experience in technology transfer and scale-up of drug substance processes is a plus.
  • Relevant experience in data interpretation and utilization, knowledge of applied statistics is an asset.
  • Understanding of operations & GMP manufacturing is an asset.
  • Ability to influence and negotiate at all levels of the organization in order to meet objective or deliverable.
  • Team spirit and a positive attitude.
  • Autonomy, scientific rigor, analytical mindset.
  • Good organization skills (day-to-day operations and lab management).
  • Ability to drive change.
  • Flexible thinking and be open-minded.
  • Strong networking skills and have scientific curiosity.
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