Farmacotechnologie en Biofarmacie
KU Leuven
Leuven
6 dagen geleden
  • The work will be performed in the Drug Delivery and Disposition research group (Department of Pharmaceutical and Pharmacological Sciences;
  • KU Leuven) under the direct supervision of Prof. Patrick AugustijnsKU Leuven is one of the top 50 universities in the world (top 10 in Europe) according to the "Times Higher Education" ranking, and ranks #7 (top in Europe) in the "World’s Most Innovative Universities" ranking elaborated by Reuters.

    KU Leuven offers an exciting multi-disciplinary research environment, a broad range of training courses for PhD students, and full social and medical insurance.

    Profile : Master degree in Pharmaceutical Sciences or in Biomedical Sciences

  • Research experience : Master thesis work and / or experience in pharmaceutical sciences
  • Communication skills : Ability to work both independently and in a team, direct communication style. Fluency in spoken and written English is mandatory.
  • The PhD student will assess the impact of transporters and enzymes on drug disposition in the colonic mucosa from healthy volunteers and colorectal cancer patients.

    Initially, protein levels of relevant transporters and enzymes will be compared in colonic biopsies of healthy volunteers versus colorectal cancer patients (in collaboration with the University Hospitals Leuven).

    The quantification of transporter and enzyme abundance will be performed in collaboration with Uppsala University .

    To assess the functionality of transporters and enzymes, the permeability of colonic biopsies for selected model substrates will be assessed in ussing chambers in the presence and in the absence of inhibitors.

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