Senior Principal Scientist Biotransformations
Johnson & Johnson
Beerse, Belgium
4 dagen geleden

Johnson & Johnson , founded in 1886, is the world's most comprehensive and broadly based manufacturer of health care products, as well as a provider of related services, for the consumer, pharmaceutical and medical devices and diagnostics markets.

Johnson & Johnson has more than 200 operating companies in 57 countries around the world employing more than 100,000 employees and selling products in more than 175 countries.

The fundamental objective of Johnson & Johnson is to provide scientifically sound, high quality products and services to help heal, cure disease and improve the quality of life.

Johnson & Johnson’s pharmaceutical businesses operate under the Janssen name. Janssen Pharmaceutica joined the Johnson & Johnson group in 1961.

Today, it is one of the most innovative pharmaceutical companies in the world and employs more than 4,000 professionals in Belgium.

The research and development centre in Beerse, Belgium develops products for a wide range of disease areas.

For our laboratory in Beerse, Belgium, we are looking for a

Senior) Principal Scientist, Biotransformation

Responsibilities

The (senior) principal scientist within the Drug Metabolism & Pharmacokinetics department will take a leading role in designing and interpreting biotransformation and metabolism studies, all aimed at improving our success in bringing differentiated medicines to patients.

The individual in this role will be asked :

  • To manage and coordinate metabolite profiling and identification studies, including design, plan and conduct of in vitro incubations, perform high quality analysis and to write high quality scientific reports
  • To perform liquid chromatography analysis with MS, UV and radioactive detection, including method development and data analysis and interpretation
  • To put data into broader context, suggest and develop follow-up experiments and present and discuss data and / or studies with multidisciplinary project teams
  • To keep abreast with the current advances in MS, automation and related technologies and apply new technologies and methods to increase sensitivity, quality and throughput for accelerating research and improving the quality of scientific data
  • Qualifications

  • PhD in Medicinal / Organic Chemistry, Pharmaceutical Sciences, Biochemistry, Pharmacokinetics, Drug Metabolism or related field with more than 10 years of experience in Pharma R&D
  • 10 years hands-on experience in metabolite structure elucidation using mass spectrometry
  • In depth knowledge of biotransformation reactions and enzymes involved
  • Advanced hands-on experience in imaging MS, oligonucleotide analysis, protein analysis or experience in interpretation of NMR spectra is an asset
  • Clear interest in the application of bioinformatics
  • Experience in maintenance of chromatography and mass spectrometry instrumentation and developing and troubleshooting LC / RAD and LC / high-resolution MS assays
  • Ability to independently diagnose and tackle complex technical and scientific problems
  • High level of professional and personal flexibility, creativity and sense of responsibility
  • Team player with strong interpersonal skills in an international team setting, including a matrix environment
  • The working language is English
  • Seniority level is currently open and will be selected in relation to experience

    Johnson & Johnson Family of Companies are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law.

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