Laboratorium voor Biosignalering & Therapeutica
KU Leuven
14 dagen geleden

The Laboratory of Biosignaling & Therapeutics, headed by Prof. Mathieu Bollen, has a long-standing interest in the regulation of proteins by reversible phosphorylation.

A position is available for a motivated PhD student to explore how protein kinases and phosphatases work together to generate pulse-like signaling responses.

You have a good background in basic sciences.

You are willing to learn and adopt a variety of techniques of biochemistry, molecular biology and cell biology.

  • You have excellent oral and written communication skills, and have a good knowledge of English.
  • You aim for perfection and are practically skillful.
  • You are ambitious, inventive and have a long-term vision.
  • You are willing and capable to work as a team member.
  • Research project :

    We have recently identified a biochemical timer that controls the mid-mitotic checkpoint.This timer stems from the integration of a counteracting kinase and phosphatase, and serves to activate the checkpoint before a sensor-

    dependent mechanism becomes operational. Our next goal is to explore whether other checkpoints associated with DNA replication and cell division are also governed by consecutive timer-

    sensor mechanisms, and to develop the therapeutic potential of such timers. The practical work will involve a combination of biochemistry, molecular biology and cell imaging.

    References :

  • Qian et al., Mol. Cell 68 (2017), 715-730
  • Gelens et al., Trends Cell Biol. 28 (2018), 6-21
  • Qian et al., Bioessays, (2019), 41(3) : e1800217. doi : 10.1002 / bies.201800217
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